Advanced HRV Analysis
RMSSD epochs: 22,740 | HR measurements: 182,298
DFA alpha-1 (RMSSD-Epoch Proxy)
Abnormal1.1092
Applied to RMSSD epochs (not RR intervals) - ref ~1.0 (not directly comparable) | 95% KI: (1.064, 1.109)
Sample Entropy
Low1.5534
Healthy: 1.5-2.5 | normal
Toichi CVI (vagal)
Low2.1147
Healthy: 3.255
Allostatic Load
2/7
mild
Baevsky SI
2.93
Normal: <150 | normal
Cosinor Amplitude
Low5.22bpm
Healthy: 15-25 bpm | Acrophase: 09:29
RQA Determinism
Low0.4451
Healthy: >0.6 | moderately_reduced
Nightly HR CV
Elevated13.45%
Mean: 73.5 bpm | high_variability
REPORT SECTION
1. Proxy Frequency Spectrum (Lomb-Scargle)
Note: Analysis based on 5-minute RMSSD epochs (not beat-to-beat RR intervals).
Nyquist frequency is limited to ~0.00167 Hz, so the table below uses proxy bands across the
accessible spectrum only. These labels are heuristic and do not support standard LF/HF physiology claims.
| Band | Power | Proportion | Interpretation |
|---|---|---|---|
| Lower proxy band | 0.0 | 6.3% | Lowest third of accessible RMSSD-epoch spectrum |
| Mid proxy band | 0.0 | 75.6% | Middle third of accessible RMSSD-epoch spectrum |
| Upper proxy band | 0.0 | 18.2% | Upper third of accessible RMSSD-epoch spectrum |
| Upper/lower proxy ratio | 4.156 | Heuristic spectral balance only; not a standard sympathovagal index | |
REPORT SECTION
2. Multiscale Entropy (MSE)
Pattern: High entropy preserved - possible inflammatory pattern
Low-scale mean: 0.6658 | High-scale mean: 0.7802
Costa et al. 2005: Healthy systems show high entropy across all scales. Neuropathic disease shows decline at high scales.
REPORT SECTION
3. Recurrence Quantification Analysis (RQA)
| Metric | Value | Interpretation |
|---|---|---|
| Recurrence Rate (RR) | 0.0032 | Proportion of recurrent states |
| Determinism (DET) | 0.4451 | Reduced predictability |
| Laminarity (LAM) | 0.2021 | Degree of intermittency |
| Diagonal Entropy | 1.1499 | Complexity of diagonal lines |
Moderately reduced determinism
REPORT SECTION
4. RMSSD-Epoch DFA (Proxy)
Note: DFA is originally designed for beat-to-beat RR-interval time series.
Applied here to 5-minute RMSSD epochs as a proxy. Reference values from RR-interval studies;
RMSSD-epoch DFA values are not directly comparable.
| Parameter | Value | 95% CI | Reference (RR-interval literature) |
|---|---|---|---|
| alpha-1 (short-term) | 1.1092 | (1.064, 1.109) | ~1.0 (RR-interval ref; proxy may differ) |
| alpha-2 (long-term) | 0.9957 | (0.876, 0.996) | ~1.0 (RR-interval ref; proxy may differ) |
| alpha (full) | 0.924 | - | ~1.0 (RR-interval ref) |
Within normal range (RMSSD-epoke-proxy; RR-intervall-terskel ~1.0 - ikke validert for denne metoden)
REPORT SECTION
5. Approximate Entropy (ApEn) and Sample Entropy (SampEn)
| Metric | Value | Parameters | Healthy Reference |
|---|---|---|---|
| ApEn | 1.5808 | m=2, r=3.0883 | ~1.0-1.5 |
| SampEn | 1.5534 | m=2, r=3.0883 | ~1.5-2.5 |
Normal complexity
REPORT SECTION
6. Hjorth Parameters
| Parameter | Value | Description |
|---|---|---|
| Activity | 238.4447 ms2 | Signal variance (power) |
| Mobility | 0.5697 | Mean frequency (low = monotonous signal) |
| Complexity | 2.7723 | Rate of frequency change |
REPORT SECTION
7. Baevsky Stress Index (SI)
| Component | Value |
|---|---|
| AMo (mode amplitude) | 5.57% |
| Mo (mode) | 8.25 ms |
| MxDMn (range) | 115.0 ms |
| SI (scaled) | 2.93 |
Normal stress level
Reference (Baevsky 2002): Normal <150, Moderate 150-500, High >500, Pathological >1000
Reference (Baevsky 2002): Normal <150, Moderate 150-500, High >500, Pathological >1000
REPORT SECTION
8. Toichi CVI/CSI (Vagal/Sympathetic Index)
| Parameter | Patient | Healthy Reference | % of Normal |
|---|---|---|---|
| SD1 (vagal) | 6.22 ms | 30 ms | 20.7% |
| SD2 (sympathetic) | 20.934 ms | 60 ms | 34.9% |
| CVI | 2.1147 | 3.255 | - |
| CSI | 3.3654 | 2.0 | - |
CVI=2.11 (healthy ref: 3.26) - severely reduced vagal tone. CSI=3.37 (healthy ref: 2.0) - sympathetic dominance.
REPORT SECTION
9. Cosinor Circadian Analysis (Heart Rate)
| Parameter | Value | Reference |
|---|---|---|
| MESOR | 85.8 bpm | 60-80 bpm (healthy) |
| Amplitude | 5.22 bpm | 15-25 bpm |
| Acrophase | 09:29 | 14:00-17:00 |
| R2 | 0.0391 | >0.3 for significant rhythm |
Flattened circadian rhythm
REPORT SECTION
10. HR Complexity (Permutation and Spectral Entropy)
| Metric | Value | Healthy Reference |
|---|---|---|
| Permutation Entropy (PE) | 0.9752 | >0.85 |
| Spectral Entropy (SE) | 0.6903 | >0.80 |
Normal ordinal pattern complexity
REPORT SECTION
11. Night-to-Night HR Variability
| Parameter | Value |
|---|---|
| Number of Nights | 297 |
| Mean Nocturnal HR | 73.5 bpm |
| SD Nocturnal HR | 9.88 bpm |
| CV | 13.45% |
| Min-Max | 56.5 - 113.9 bpm |
| Trend | stable trend (-0.08 bpm/night) |
REPORT SECTION
12. Wearable Allostatic Load Score
2 / 7 MILD
| Biomarker | Value | Threshold | Status |
|---|---|---|---|
| Hr Avg Sleep | 73.5 bpm | > 80 bpm | OK |
| Hrv Rmssd | 21.8 ms | > 15 ms | OK |
| Sleep Efficiency | 73.2 % | < 85 % | EXCEEDED |
| Temp Deviation | 0.244 °C | > 0.5 °C | OK |
| Spo2 | 95.62 % | < 95 % | OK |
| Deep Sleep Pct | 17.8 % | < 10 % | OK |
| Rem Sleep Pct | 13.4 % | < 15 % | EXCEEDED |
Mild allostatic load (2/7)
REPORT SECTION
Clinical Summary
Key Findings:
Advanced analysis of 22,740 RMSSD epochs and 182,298 heart rate measurements confirms severe autonomic dysfunction in this post-hsct patient.
Key Metrics:
Clinical Interpretation:
Combined analyses show a pattern consistent with severe autonomic neuropathy with both parasympathetic failure (low CVI, low SampEn, low SD1) and chronodisruption (low cosinor amplitude). MSE pattern (inflammatory) and DFA findings support loss of fractal dynamics. The high allostatic load (2/7) indicates systemic physiological stress exceeding adaptive capacity.
Analysis based on Oura Ring Gen 4 data (Jan-Mar 2026). RMSSD epochs are 5-minute intervals during sleep. DFA and SampEn are computed from RMSSD epochs (proxy) - not beat-to-beat RR intervals. Reference values from RR-interval studies are not directly comparable. Frequency domain values are approximations based on Lomb-Scargle periodogram, not beat-to-beat analysis, and should be interpreted as relative indicators. Population norms for RMSSD are from controlled clinical 5-minute recordings; consumer wearable nocturnal values may differ.
Advanced analysis of 22,740 RMSSD epochs and 182,298 heart rate measurements confirms severe autonomic dysfunction in this post-hsct patient.
Key Metrics:
- DFA alpha-1 (RMSSD-Epoch Proxy) = 1.1092 (RR-interval ref ~1.0; proxy may differ): Within normal range (RMSSD-epoke-proxy; RR-intervall-terskel ~1.0 - ikke validert for denne metoden)
- SampEn = 1.5534 (RR-interval ref 1.5-2.5; RMSSD-epoch may differ): Normal complexity
- Toichi CVI = 2.1147 (reference 3.255): Severely reduced vagal tone
- Cosinor amplitude = 5.22 bpm (reference 15-25): Flattened circadian rhythm
- Allostatic load score = 2/7: mild
- RQA determinism = 0.4451: Moderately reduced determinism
Clinical Interpretation:
Combined analyses show a pattern consistent with severe autonomic neuropathy with both parasympathetic failure (low CVI, low SampEn, low SD1) and chronodisruption (low cosinor amplitude). MSE pattern (inflammatory) and DFA findings support loss of fractal dynamics. The high allostatic load (2/7) indicates systemic physiological stress exceeding adaptive capacity.
Analysis based on Oura Ring Gen 4 data (Jan-Mar 2026). RMSSD epochs are 5-minute intervals during sleep. DFA and SampEn are computed from RMSSD epochs (proxy) - not beat-to-beat RR intervals. Reference values from RR-interval studies are not directly comparable. Frequency domain values are approximations based on Lomb-Scargle periodogram, not beat-to-beat analysis, and should be interpreted as relative indicators. Population norms for RMSSD are from controlled clinical 5-minute recordings; consumer wearable nocturnal values may differ.