Treatment Response Report

Ruxolitinib + Bisoprolol: comprehensive multi-system assessment for Drs Schoemans and Wolff

Generated 2026-10-07 06:22 · Post-HSCT Patient · Data Jan 08, 2026 to Oct 06, 2026 · Day 205 post-treatment

EXECUTIVE

Executive Summary

Days on Jakavi

Info

205.0days

Ruxolitinib 10 mg BID since Mar 16

Days on Bisoprolol

Info

182.0days

2.5 mg daily since Apr 08

Current HRV

Watch

20.0ms

Last night RMSSD

Lowest HR

In range

56bpm

Last night minimum

HRV Change

In range

+198%

Pre-tx 9.0 ms vs Jak+Biso 27.0 ms

HR Change

In range

-17.2bpm

Pre-tx 77 bpm vs Jak+Biso 60 bpm

Two-hit autonomic recovery model: Ruxolitinib (Day 205) addresses GvHD-driven inflammation. Bisoprolol (Day 182) provides direct chronotropic support. Together, HRV has increased +198% and lowest sleeping HR shifted -17.2 bpm vs pre-treatment. The combination is producing measurable autonomic recovery that neither drug achieved alone.

TIMELINE

Treatment Timeline (Day-by-Day)

Date	Day	HRV	Low HR	Avg HR	Eff%	Sleep h	Deep h	REM h	Temp	Ready	Recov	Steps	Phase
2026-03-17	D+1	8.0	77	84	78	5.7	1.1	0.5	-0.36	64	48	1454	Jak
2026-03-20	D+4	9.0	74	82	83	5.8	1.3	0.9	-0.12	70	67	694	Jak
2026-03-21	D+5	11.0	73	81	84	6.0	0.8	1.4	+0.08	77	45	2478	Jak
2026-03-22	D+6	9.0	73	82	80	5.4	1.2	0.8	-0.31	63	9	1910	Jak
2026-03-23	D+7	14.0	67	76	83	7.9	0.9	1.9	+0.01	77	92	6678	Jak
2026-03-24	D+8	10.0	74	79	82	4.9	1.3	0.8	-0.16	63	53	2697	Jak
2026-03-25	D+9	12.0	75	79	77	4.6	1.0	0.7	-0.24	68	58	4227	Jak
2026-03-26	D+10	11.0	70	83	76	7.7	1.1	1.6	+0.35	69	24	3332	Jak
2026-03-27	D+11	11.0	73	79	87	5.3	1.5	0.8	-0.03	71	77	2421	Jak
2026-03-28	D+12	10.0	74	81	82	5.9	1.1	0.5	-0.14	73	71	1919	Jak
2026-03-29	D+13	9.0	68	83	78	7.1	0.7	1.1	-0.02	69	37	1922	Jak
2026-03-30	D+14	14.0	73	79	78	4.5	0.9	0.4	-0.51	71	83	3727	Jak
2026-03-31	D+15	12.0	68	79	78	8.1	0.8	1.2	+0.35	77	100	4876	Jak
2026-04-01	D+16	10.0	77	83	83	4.8	0.3	0.8	+0.04	63	56	1366	Jak
2026-04-03	D+18	9.0	73	82	80	6.7	1.4	1.2	-0.16	76	87	1376	Jak
2026-04-04	D+19	11.0	70	79	83	6.7	1.4	1.2	+0.06	74	59	1847	Jak
2026-04-05	D+20	10.0	74	81	69	4.5	1.3	0.6	-0.44	66	55	9941	Jak
2026-04-06	D+21	6.0	84	96	81	6.8	1.6	1.1	+0.48	49	31	12488	Jak
2026-04-07	D+22	13.0	68	79	77	3.8	0.5	0.3	-0.53	60	45	11190	Jak
2026-04-08	D+23	7.0	85	98	67	8.3	2.5	1.1	+0.62	50	98	13049	Jak+BB
2026-04-10	D+25	23.0	61	69	89	7.4	1.2	0.9	+0.05	70	100	2275	Jak+BB
2026-04-11	D+26	12.0	68	75	79	6.2	1.3	1.3	+0.26	68	100	1388	Jak+BB
2026-04-12	D+27	23.0	65	71	79	8.1	1.2	1.3	+0.10	77	100	1525	Jak+BB
2026-04-13	D+28	26.0	68	76	81	7.4	1.6	1.0	+0.70	73	82	3397	Jak+BB
2026-04-14	D+29	35.0	61	71	85	6.6	1.0	0.6	+0.05	72	60	4960	Jak+BB
2026-04-15	D+30	24.0	63	67	83	4.3	1.0	0.0	-0.24	74	79	2540	Jak+BB
2026-04-16	D+31	24.0	66	74	68	7.8	1.4	0.9	+0.25	84	100	3324	Jak+BB
2026-04-17	D+32	41.0	64	73	87	6.3	0.9	0.5	-0.25	74	46	3229	Jak+BB
2026-04-18	D+33	40.0	62	71	85	7.9	1.2	0.5	+0.01	82	100	5009	Jak+BB
2026-04-19	D+34	36.0	63	70	85	6.1	1.2	1.3	-0.22	76	73	2627	Jak+BB
2026-04-20	D+35	37.0	64	72	84	5.4	0.6	1.1	-0.46	77	75	2402	Jak+BB
2026-04-21	D+36	36.0	60	68	89	7.6	0.5	1.0	-0.53	80	83	2546	Jak+BB
2026-04-22	D+37	33.0	66	73	79	6.3	1.1	0.3	-0.16	74	30	7330	Jak+BB
2026-04-23	D+38	27.0	65	72	79	5.7	1.2	0.7	+0.17	78	82	3251	Jak+BB
2026-04-24	D+39	29.0	65	74	83	10.2	1.4	1.2	+0.55	80	100	4032	Jak+BB
2026-04-25	D+40	51.0	63	70	75	7.7	1.1	0.9	+0.16	76	54	1878	Jak+BB
2026-04-26	D+41	27.0	62	70	86	8.0	1.6	1.4	+0.14	86	78	1963	Jak+BB
2026-04-27	D+42	43.0	57	68	82	6.7	0.3	1.3	+0.23	73	48	11898	Jak+BB
2026-04-28	D+43	41.0	73	79	72	8.0	1.5	0.9	+0.40	78	100	1254	Jak+BB
2026-04-29	D+44	41.0	52	61	87	9.7	1.6	1.1	+0.37	82	97	2326	Jak+BB
2026-04-30	D+45	34.0	57	68	83	6.3	0.8	0.7	-0.25	74	55	4364	Jak+BB
2026-05-01	D+46	26.0	67	78	83	8.0	1.6	1.6	+0.33	88	78	3354	Jak+BB
2026-05-02	D+47	25.0	59	68	83	6.3	0.7	1.2	-0.21	78	63	1827	Jak+BB
2026-05-03	D+48	29.0	58	66	83	7.3	1.0	1.2	-0.44	80	63	2619	Jak+BB
2026-05-04	D+49	37.0	56	64	81	6.5	1.0	0.9	-0.23	76	66	2199	Jak+BB
2026-05-05	D+50	33.0	56	62	85	6.5	1.7	1.4	-0.49	83	94	5291	Jak+BB
2026-05-06	D+51	24.0	55	62	89	6.8	1.0	1.1	-0.51	79	74	1564	Jak+BB
2026-05-07	D+52	27.0	61	70	86	7.1	0.7	1.0	-0.15	84	85	1971	Jak+BB
2026-05-08	D+53	22.0	58	66	89	4.9	1.3	1.0	-0.08	75	25	6600	Jak+BB
2026-05-09	D+54	24.0	61	74	85	7.5	0.6	1.5	-0.03	80	50	769	Jak+BB
2026-05-11	D+56	22.0	62	71	86	5.7	1.5	0.9	-0.16	81	66	1243	Jak+BB
2026-05-12	D+57	33.0	56	68	86	8.2	1.4	1.6	+0.06	86	87	2083	Jak+BB
2026-05-13	D+58	23.0	61	72	87	5.1	1.2	0.8	-0.22	75	38	1702	Jak+BB
2026-05-14	D+59	29.0	57	66	89	8.2	0.9	1.3	-0.04	82	58	1912	Jak+BB
2026-05-15	D+60	26.0	61	68	84	5.3	1.2	0.4	-0.04	76	40	2288	Jak+BB
2026-05-16	D+61	37.0	55	64	82	6.5	1.5	0.9	-0.35	77	53	1430	Jak+BB
2026-05-17	D+62	28.0	59	67	81	5.9	0.3	0.7	+0.03	79	79	4264	Jak+BB
2026-05-18	D+63	24.0	35	63	82	6.6	0.9	0.6	-0.13	69	82	6717	Jak+BB
2026-05-19	D+64	13.0	81	84	75	3.4	0.8	0.2	+0.92	57	100	10708	Jak+BB
2026-05-19	D+64	12.0	76	84	82	5.6	0.6	0.2	+0.92	57	100	10708	Jak+BB
2026-05-20	D+65	43.0	54	66	81	8.2	1.9	1.9	-0.02	81	97	13009	Jak+BB
2026-05-21	D+66	29.0	73	82	88	6.9	1.0	0.6	+0.51	60	20	7055	Jak+BB
2026-05-22	D+67	36.0	61	73	84	8.4	1.4	1.3	+0.34	77	39	10503	Jak+BB
2026-05-23	D+68	29.0	65	78	86	6.7	1.1	0.7	+0.17	72	35	12879	Jak+BB
2026-05-24	D+69	12.0	72	78	83	5.9	1.8	0.9	-0.10	70	100	415	Jak+BB
2026-05-25	D+70	34.0	63	75	87	9.0	1.1	1.5	+0.21	87	100	10840	Jak+BB
2026-05-26	D+71	8.0	74	80	75	6.6	1.6	0.3	+0.51	62	100	1391	Jak+BB
2026-05-27	D+72	30.0	59	70	84	5.9	0.7	0.7	+0.02	67	11	13005	Jak+BB
2026-05-28	D+73	56.0	72	85	83	7.3	1.9	1.2	+0.22	70	75	12879	Jak+BB
2026-05-29	D+74	31.0	70	81	81	7.0	1.2	0.9	+0.69	66	57	7029	Jak+BB
2026-05-30	D+75	25.0	77	84	73	4.8	2.1	0.4	+0.07	64	100	8941	Jak+BB
2026-06-01	D+77	36.0	62	70	82	3.2	0.5	0.9	+0.49	80	100	3981	Jak+BB
2026-06-01	D+77	41.0	59	70	84	5.5	1.1	1.7	+0.49	80	100	3981	Jak+BB
2026-06-02	D+78	38.0	60	65	75	3.7	0.7	0.4	-0.07	66	44	10000	Jak+BB
2026-06-03	D+79	25.0	52	63	88	8.6	1.7	2.1	-0.02	72	43	1087	Jak+BB
2026-06-04	D+80	20.0	48	69	58	8.4	0.8	0.8	+0.25	65	34	4623	Jak+BB
2026-06-05	D+81	29.0	56	64	85	9.3	1.1	1.3	-0.11	78	61	2028	Jak+BB
2026-06-06	D+82	27.0	56	63	73	5.3	1.8	1.0	-0.71	79	100	1846	Jak+BB
2026-06-07	D+83	22.0	57	66	88	7.6	1.0	1.8	-0.32	80	53	1689	Jak+BB
2026-06-08	D+84	31.0	53	64	90	5.8	1.2	1.3	-0.38	74	45	4084	Jak+BB
2026-06-09	D+85	22.0	60	66	86	7.2	1.4	2.0	-0.07	86	88	1874	Jak+BB
2026-06-10	D+86	21.0	60	70	82	6.3	0.7	1.1	+0.42	77	54	3860	Jak+BB
2026-06-11	D+87	13.0	64	76	67	6.6	1.5	0.9	+1.96	65	94	901	Jak+BB
2026-06-12	D+88	12.0	64	73	82	8.0	1.2	1.2	+0.81	72	45	3052	Jak+BB
2026-06-13	D+89	30.0	53	62	87	9.6	1.6	2.1	-0.31	83	78	669	Jak+BB
2026-06-14	D+90	29.0	55	64	88	8.1	1.1	1.8	-0.28	83	88	896	Jak+BB
2026-06-15	D+91	41.0	53	62	85	7.4	1.6	1.4	-0.04	78	28	6040	Jak+BB
2026-06-16	D+92	27.0	56	62	88	5.6	1.1	1.3	-0.05	76	40	2310	Jak+BB
2026-06-17	D+93	18.0	61	67	82	5.7	1.5	0.7	+0.04	84	87	371	Jak+BB
2026-06-18	D+94	31.0	57	65	84	8.6	1.5	1.9	+0.04	91	100	1076	Jak+BB
2026-06-19	D+95	27.0	55	64	82	7.1	1.4	1.0	+0.09	82	70	4710	Jak+BB
2026-06-20	D+96	9.0	72	82	63	6.8	2.0	0.9	+0.70	62	100	2862	Jak+BB
2026-06-21	D+97	41.0	54	62	87	8.0	1.4	1.6	-0.25	84	57	1569	Jak+BB
2026-06-22	D+98	27.0	55	64	81	4.4	1.0	1.1	-0.19	73	55	1010	Jak+BB
2026-06-23	D+99	27.0	59	66	84	6.2	1.3	0.9	+0.40	80	85	2249	Jak+BB
2026-06-24	D+100	31.0	54	62	88	8.9	2.0	2.2	+0.06	84	96	4641	Jak+BB
2026-06-25	D+101	28.0	58	65	86	6.5	1.7	1.2	-0.01	77	48	2429	Jak+BB
2026-06-26	D+102	20.0	58	66	83	6.5	1.9	0.9	+0.05	79	60	1936	Jak+BB
2026-06-27	D+103	20.0	60	70	85	7.8	1.7	1.6	+0.12	83	55	1429	Jak+BB
2026-06-28	D+104	34.0	55	62	83	7.0	1.2	1.6	-0.18	83	100	838	Jak+BB
2026-06-29	D+105	33.0	55	63	86	8.0	1.4	1.3	+0.00	87	100	8435	Jak+BB
2026-06-30	D+106	12.0	64	75	84	6.1	1.2	0.9	+0.17	73	44	8570	Jak+BB
2026-07-02	D+108	34.0	55	65	83	8.8	1.4	2.0	-0.20	83	53	1192	Jak+BB
2026-07-03	D+109	37.0	53	60	86	7.2	0.7	1.8	-0.09	83	99	1128	Jak+BB
2026-07-04	D+110	32.0	55	66	84	9.5	1.4	2.0	+0.20	90	100	2516	Jak+BB
2026-07-05	D+111	31.0	57	65	86	7.3	1.7	2.0	-0.02	88	89	2011	Jak+BB
2026-07-06	D+112	30.0	54	59	83	6.1	1.9	1.4	-0.37	84	77	2414	Jak+BB
2026-07-07	D+113	27.0	55	63	87	7.3	1.4	2.1	-0.33	92	100	2093	Jak+BB
2026-07-08	D+114	16.0	61	70	78	6.6	1.6	1.5	-0.23	86	70	3073	Jak+BB
2026-07-09	D+115	26.0	52	62	80	5.9	1.6	1.4	-0.41	79	41	1866	Jak+BB
2026-07-10	D+116	19.0	58	68	78	4.5	0.7	0.8	-0.18	75	21	7361	Jak+BB
2026-07-11	D+117	6.0	86	94	58	8.1	2.7	0.6	+1.20	39	100	499	Jak+BB
2026-07-12	D+118	17.0	62	74	84	6.9	1.4	0.7	+0.44	73	34	2366	Jak+BB
2026-07-13	D+119	28.0	58	65	83	4.3	0.8	0.9	-0.13	68	42	3816	Jak+BB
2026-07-14	D+120	39.0	55	64	90	6.2	1.1	1.7	-0.12	75	66	8344	Jak+BB
2026-07-15	D+121	23.0	57	66	85	6.8	1.5	1.2	-0.04	71	54	6086	Jak+BB
2026-07-16	D+122	35.0	52	61	89	7.2	1.4	1.6	-0.21	77	77	8913	Jak+BB
2026-07-17	D+123	30.0	56	63	84	6.4	1.9	0.9	+0.04	70	31	7269	Jak+BB
2026-07-18	D+124	11.0	65	85	77	10.0	1.5	1.0	+0.67	58	23	1590	Jak+BB
2026-07-19	D+125	20.0	61	73	85	7.5	1.4	1.1	+0.13	81	79	8001	Jak+BB
2026-07-20	D+126	34.0	64	75	83	5.7	0.9	0.6	-0.40	63	11	3085	Jak+BB
2026-07-21	D+127	28.0	54	65	84	7.5	1.6	1.1	+0.12	82	83	6426	Jak+BB
2026-07-22	D+128	17.0	69	73	80	5.1	1.4	0.6	-0.12	63	68	8224	Jak+BB
2026-07-23	D+129	17.0	64	68	85	6.1	0.7	1.0	-0.22	75	98	7784	Jak+BB
2026-07-24	D+130	29.0	66	74	80	6.6	1.2	0.9	-0.51	65	20	2071	Jak+BB
2026-07-25	D+131	29.0	63	71	83	7.4	0.7	1.3	-0.04	73	30	1415	Jak+BB
2026-07-26	D+132	31.0	58	70	87	7.7	0.7	1.6	+0.24	82	70	8396	Jak+BB
2026-07-27	D+133	22.0	62	70	85	6.1	0.8	0.9	-0.43	71	55	7684	Jak+BB
2026-07-28	D+134	39.0	68	76	83	8.4	1.2	1.1	-0.18	73	49	8394	Jak+BB
2026-07-29	D+135	26.0	59	69	89	7.0	1.1	1.1	-0.30	78	49	1715	Jak+BB
2026-07-30	D+136	24.0	58	68	88	7.6	1.3	1.4	-0.13	87	77	8297	Jak+BB
2026-07-31	D+137	15.0	63	72	84	6.7	1.4	1.7	-0.32	72	42	2004	Jak+BB
2026-08-01	D+138	29.0	60	69	83	4.5	0.8	0.6	-0.46	74	25	10615	Jak+BB
2026-08-02	D+139	8.0	78	88	79	6.3	1.5	0.9	+0.27	55	30	1957	Jak+BB
2026-08-03	D+140	26.0	68	75	85	6.5	0.7	0.8	-0.18	67	22	1140	Jak+BB
2026-08-04	D+141	24.0	59	70	81	9.8	1.6	1.1	+0.51	77	59	11678	Jak+BB
2026-08-05	D+142	24.0	59	65	89	7.1	1.1	1.5	-0.19	76	78	1907	Jak+BB
2026-08-06	D+143	30.0	54	62	90	6.5	1.6	1.7	-0.55	78	48	5847	Jak+BB
2026-08-07	D+144	26.0	54	64	89	7.4	2.0	1.8	-0.20	77	46	3388	Jak+BB
2026-08-08	D+145	26.0	53	62	89	7.0	1.8	1.6	-0.20	77	37	7398	Jak+BB
2026-08-09	D+146	27.0	55	64	81	8.4	2.4	1.6	+0.24	83	65	7391	Jak+BB
2026-08-10	D+147	29.0	51	61	88	6.8	1.3	1.4	-0.37	75	30	3777	Jak+BB
2026-08-11	D+148	36.0	51	60	87	6.0	0.9	1.0	-0.24	75	49	6934	Jak+BB
2026-08-12	D+149	21.0	57	64	89	9.1	1.8	1.9	+0.09	88	95	4741	Jak+BB
2026-08-13	D+150	25.0	52	63	85	8.8	2.1	2.1	+0.35	79	35	7749	Jak+BB
2026-08-14	D+151	26.0	55	64	89	6.9	1.6	1.6	+0.16	80	54	5099	Jak+BB
2026-08-15	D+152	29.0	54	61	89	7.9	1.9	1.8	+0.03	88	100	3957	Jak+BB
2026-08-16	D+153	10.0	65	81	65	8.8	2.1	0.8	+0.92	60	100	350	Jak+BB
2026-08-17	D+154	23.0	57	68	78	7.8	0.7	0.5	+1.07	68	82	3111	Jak+BB
2026-08-18	D+155	35.0	54	60	88	7.0	1.2	1.5	-0.15	84	91	1595	Jak+BB
2026-08-19	D+156	30.0	54	62	85	7.0	1.8	1.7	+0.10	85	100	11298	Jak+BB
2026-08-20	D+157	29.0	54	64	87	7.8	1.5	1.8	-0.03	86	93	2229	Jak+BB
2026-08-21	D+158	34.0	52	58	88	7.7	1.2	1.5	-0.08	88	100	2503	Jak+BB
2026-08-22	D+159	25.0	55	62	84	8.0	1.9	1.8	-0.02	88	100	9598	Jak+BB
2026-08-23	D+160	8.0	81	91	68	5.5	2.0	0.4	+0.68	46	82	245	Jak+BB
2026-08-24	D+161	37.0	54	65	92	11.3	1.0	2.3	+0.79	78	83	4050	Jak+BB
2026-08-25	D+162	55.0	49	59	88	4.7	1.3	1.4	-0.06	68	22	11774	Jak+BB
2026-08-26	D+163	25.0	55	66	84	7.5	1.9	1.9	+0.32	78	34	8405	Jak+BB
2026-08-27	D+164	32.0	55	62	90	6.9	1.4	1.7	-0.12	84	69	3514	Jak+BB
2026-08-28	D+165	29.0	54	62	90	8.1	1.6	1.8	-0.30	86	61	1701	Jak+BB
2026-08-29	D+166	33.0	56	62	85	7.5	1.7	1.9	-0.20	89	100	2433	Jak+BB
2026-08-30	D+167	17.0	58	68	84	6.7	1.4	1.6	-0.01	81	59	2127	Jak+BB
2026-08-31	D+168	29.0	58	64	86	5.7	1.6	1.2	-0.17	80	78	2652	Jak+BB
2026-09-01	D+169	47.0	49	56	87	5.4	1.6	1.1	-0.34	80	96	1814	Jak+BB
2026-09-02	D+170	40.0	52	58	87	7.6	1.3	1.4	-0.21	87	95	4837	Jak+BB
2026-09-03	D+171	39.0	51	59	88	6.8	1.9	1.9	-0.17	84	77	3392	Jak+BB
2026-09-04	D+172	32.0	54	64	88	6.4	0.9	1.5	-0.03	84	67	3063	Jak+BB
2026-09-05	D+173	30.0	55	61	84	6.0	1.6	1.0	-0.26	82	48	1750	Jak+BB
2026-09-06	D+174	28.0	54	65	89	7.0	1.4	1.6	+0.04	83	36	1485	Jak+BB
2026-09-07	D+175	40.0	50	59	90	6.2	0.9	1.2	+0.24	79	33	1302	Jak+BB
2026-09-08	D+176	16.0	65	71	84	7.1	1.6	1.4	+0.04	76	95	2348	Jak+BB
2026-09-09	D+177	51.0	51	57	90	6.4	1.7	1.2	-0.41	85	75	8133	Jak+BB
2026-09-10	D+178	22.0	56	65	84	6.0	1.3	1.2	-0.32	80	69	2417	Jak+BB
2026-09-11	D+179	11.0	63	77	85	7.6	0.9	1.2	-0.03	70	26	2972	Jak+BB
2026-09-12	D+180	18.0	60	68	86	6.4	0.9	1.4	-0.09	73	46	4536	Jak+BB
2026-09-13	D+181	10.0	76	86	68	8.9	2.3	1.5	+0.92	47	100	1316	Jak+BB
2026-09-14	D+182	42.0	56	63	82	6.4	1.1	1.4	-0.13	83	100	9257	Jak+BB
2026-09-15	D+183	29.0	55	66	88	7.7	1.4	1.8	+0.21	75	38	4089	Jak+BB
2026-09-16	D+184	23.0	58	67	81	6.4	1.8	1.2	+0.03	72	44	1914	Jak+BB
2026-09-17	D+185	20.0	65	68	75	4.8	1.3	1.4	+0.13	65	85	2235	Jak+BB
2026-09-18	D+186	28.0	55	66	85	8.0	1.4	1.5	+0.53	76	48	2045	Jak+BB
2026-09-19	D+187	28.0	59	66	92	6.1	0.7	1.4	-0.05	72	96	2047	Jak+BB
2026-09-20	D+188	23.0	55	64	89	8.1	0.8	1.8	-0.05	81	60	7763	Jak+BB
2026-09-21	D+189	18.0	59	69	71	7.9	1.1	1.5	+0.33	75	96	2663	Jak+BB
2026-09-22	D+190	20.0	59	67	78	4.8	0.6	0.9	-0.02	68	56	1929	Jak+BB
2026-09-23	D+191	24.0	57	63	88	5.5	1.7	1.2	+0.19	78	97	3088	Jak+BB
2026-09-24	D+192	23.0	53	62	85	6.6	1.5	1.1	-0.27	78	76	2132	Jak+BB
2026-09-25	D+193	13.0	68	74	82	5.4	1.4	1.2	+0.60	51	100	7354	Jak+BB
2026-09-26	D+194	20.0	59	68	84	6.4	0.9	1.1	+0.07	68	52	2385	Jak+BB
2026-09-27	D+195	12.0	66	76	75	5.9	1.3	1.4	+0.24	56	68	7682	Jak+BB
2026-09-28	D+196	18.0	61	66	87	6.5	1.1	1.4	+0.05	68	84	2440	Jak+BB
2026-09-29	D+197	21.0	59	66	89	5.8	1.3	1.1	-0.14	67	54	6831	Jak+BB
2026-09-30	D+198	14.0	62	70	84	5.8	1.5	1.2	+0.07	56	16	7553	Jak+BB
2026-10-01	D+199	24.0	57	63	90	7.5	1.7	2.1	+0.29	75	74	2369	Jak+BB
2026-10-02	D+200	26.0	58	64	84	3.1	1.3	0.7	+0.59	67	100	1719	Jak+BB
2026-10-03	D+201	28.0	52	61	87	7.8	1.7	1.8	+0.20	76	64	10073	Jak+BB
2026-10-04	D+202	23.0	59	66	86	5.9	1.4	1.2	-0.14	65	88	2276	Jak+BB
2026-10-05	D+203	27.0	56	62	82	6.4	1.8	1.4	-0.03	77	77	1963	Jak+BB
2026-10-06	D+204	20.0	56	64	87	6.2	1.0	1.1	-0.19	77	100	8120	Jak+BB

HEART

Heart & Autonomic System

Three-Period Comparison

Metric	Pre-treatment	Jakavi only	Jak + Biso	p-value
HRV (ms)	9.0	10.5	27.0	p<0.001
Lowest HR (bpm)	77	73	60	p<0.001
Avg HR (bpm)	85	81	68	p<0.001
Recovery Index	61	58	68	p=0.093

ITS beta-blocker slope (HRV): -0.03 ms/day (p=0.916, CI [-0.55, 0.49])

ITS beta-blocker slope (HR): -0.02 bpm/day (p=0.936, CI [-0.50, 0.46])

SLEEP

Sleep Architecture & Quality

Sleep Metrics by Phase

Metric	Pre-treatment	Jakavi only	Jak + Biso
Duration (h)	5.9	5.9	6.9
Efficiency (%)	79	80	83
Deep (h)	1.1	1.1	1.3
REM (h)	0.9	0.9	1.2
Light (h)	3.9	3.9	4.3
Breath rate	13.9	14.3	15.2

ACTIVITY

Activity & Physical Form

Activity Metrics by Phase

Metric	Pre-treatment	Jakavi only	Jak + Biso	p-value
Steps/day	2416	4029	4307	p<0.001
Active cal/day	175	247	274	p<0.001
Activity score	54	56	67	p<0.001

INFLAMMATION

Inflammation & Temperature

Inflammation & Temperature by Phase

Metric	Pre-treatment	Jakavi only	Jak + Biso
Temp deviation (C)	+0.06	-0.09	+0.05
SpO2 (%)	96.1	96.1	95.4
Breath rate	13.9	14.3	15.2

Note: Mean temp on Jak+Biso (+0.05 C) elevated vs Jak-only (-0.09 C). Beta-blockers can mask fever. Monitor.

DRUGS

Drug-Specific Analysis

Bayesian CausalImpact (Sequential)

Metric	Jakavi Alone (Run A)			+ Bisoprolol (Run B)
	Effect	Rel	p	Effect	Rel	p
HRV (ms)	+0.7	+7%	p=0.131	+17.2	+159%	p<0.001
Lowest HR	-3.2	-4%	p=0.013	-13.4	-18%	p<0.001
Avg HR	-3.5	-4%	p=0.042	-12.9	-16%	p<0.001
Sleep Eff %	+1.4	+2%	p=0.052	+3.2	+4%	p<0.001

Tau-U Effect Sizes

Metric	A vs B (Tau)	Effect	B vs C (Tau)	Effect
HRV	-0.192	weak	0.954	very large
Lowest HR	-0.114	weak	0.886	very large
Avg HR	-0.162	weak	0.868	very large

Two-hit model: Run A shows Jakavi produced favorable but mostly non-significant trends (immune modulation). Run B shows the beta-blocker addition produced large, statistically significant effects on HRV (+92%, p<0.001) and HR (-5.2%, p<0.001). Jakavi removes the inflammatory driver while bisoprolol provides chronotropic relief.

COMPARISON

Three-Way Comparison (Henrik / Mitch / Wenche)

Metric (recent 22d)	Henrik (36, HSCT)	Mitch (36, Stroke)	Wenche (61, Healthy)
HRV (ms)	21.9	44.4	26.7
Lowest HR (bpm)	58.5	49.9	52.3
Avg HR (bpm)	66.4	58.7	57.2
Sleep (h)	6.3	6.3	6.2
Efficiency (%)	84.0	84.9	84.0
Steps/day	4121.4	11622.0	8697.5

Context: Your 61-year-old mother (healthy control) has 1.2x your HRV despite being 25 years older. This underscores the severity of post-HSCT autonomic deficit and the clinical need for the current dual-drug intervention.

WARNINGS

Warnings & Follow-up

Active Watchpoints

Breath rate increase: +1.3 breaths/min vs pre-treatment. Monitor SpO2.
PPG noise floor: HRV values below 10 ms are near Oura sensor noise floor. Interpret single-night values cautiously.

Recommended Follow-up Labs

CBC with differential (ruxolitinib myelosuppression)
CRP / ESR (inflammation tracking)
LFTs (hepatic GvHD screening)
HEV PCR (viral clearance confirmation)
12-lead ECG (PR interval on bisoprolol)
Consider 24h Holter if resting HR drops below 55 bpm